Şiddetli hipertrigliseridemili hastalarda lipoprotein lipaz mutasyon prevalansı ve hipertrigliseridemik pankreatitin karakteristik özellikleri

Aim: We conducted a retrospective study with the aim of determining prevalence lipoprotein lipase (LPL) mutation in patients severe hypertriglyceridemia (HTG) and to differences characteristic features HTG induced acute pancreatitis (AP). Materials Methods: Seventy adults serum triglyceride (TG) level ≥500 mg/dL were included study. Baseline characteristics, LPL risk factors between those without HTG-AP compared. Results: The mean age was 43 ± 12 years, males accounted for 55.7%. Of 35 had TG <2000 mg/dL, ≥2000 mg/dL. found 19 (27.1%) cases. AP 67.1% (47 patients). Younger age, level, hemoglobin A1c (HbA1c) significantly independent development HTG-AP. When divided into groups based on levels (group 1 group 2 mg/dL) higher (51.4% vs. 82.9%). Age HbA1c lost their significance AP. relationship frequency value evaluated, specificity threshold developing be 2235 There no difference detected undetected groups. Conclusion: variant In contrast literature, cut-off points develop determined.